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Fertility Testing > Acrosome Induction Test The Acrosome Induction Test When sperm are released with the ejaculate, they undergo several changes within the female reproductive tract. These changes are necessary for fertilization. One of the most dramatic physiologic changes that occurs to the sperm is completion of the "acrosome reaction". Each sperm has a cap containing enzymes that are released when the sperm are in contact with the outer shell of the egg. Only those sperm that can undergo an acrosome reaction can enter the egg for fertilization. In the laboratory, Dr. Marmar's group has developed an "acrosome induction test" (Archives of Andrology 44:59, 2000). Results of these tests are a measure of sperm function that correlate with the outcome In Vitro Fertilization (IVF). The acrosome induction test can also be used to determine the need for IVF versus Intracytoplasmic Sperm Injection (ICSI). In addition, this test may be used to evaluate men with varicoceles to determine the best candidates for microsurgery.